本实验研究了人酸性成纤维细胞生长因子(haFGF)的体外神经营养作用。结果表明,haFGF在体外能明显促进鸡胚(E-8)脊髓组织神经突起的生长,并能明显改变新生大鼠脑星形胶质细胞的形态,使扁平、多角形紧密联接的细胞转化为具有纤维样突起的胶质细胞,同时对胶质细胞DNA合成也有一定促进作用。实验还证明,haFGF可增加体外培养新生大鼠海马神经元的存活,且大大增加神经元胞体体积及突起长度。 In this study, the in vitro neurotrophic effect of human acidic fibroblast growth factor (haFGF) was studied. The results showed that haFGF can significantly promote the neurite outgrowth in chicken embryo (E-8) spinal cord tissue in vitro and change the morphology of astrocytes in neonatal rat brain significantly, so that the flat, polygonal closely connected cells can be transformed into With fiber-like protuberance glial cells, while glial cell DNA synthesis also has a certain role in promoting. Experiments also show that, haFGF can increase the survival of cultured hippocampal neurons in vitro, and greatly increase the volume and length of neurons soma.