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目的:了解输血传播病毒(Transfusion Transmitted Virus,TTV)单独及重叠乙肝病毒(HBV)感染的临床特征,探讨其致病性。方法:用套式聚合酶链反应检测血清中TTV DNA,用ELISA法和/或PCR法对其他肝炎病毒标志物进行血清学检测。结果:肝病患者TTV DNA总的阳性率为21.9%(107/489)。从临床分型来看,TTV单独感染者以急性肝炎(AH)为多见,占75%(12/16),明显高于重叠HBV感染者13%(2/15)(x~2=11.9,P<0.01),而重叠感染者以慢性肝炎(CH)居多,占67%(10/15),明显高于单独感染者19%(3/16)(x~2=7.3,P<0.01)。结论:TTV单独感染多表现为急性肝炎,重叠HBV感染时对病情的影响不明显,提示TTV具有一定的致病性。
Objective: To investigate the clinical characteristics of transfusion transmitted virus (TTV) isolated and overlapping HBV infection and to explore its pathogenicity. Methods: Serum TTV DNA was detected by nested polymerase chain reaction, and other hepatitis virus markers were detected by ELISA and / or PCR. Results: The overall positive rate of TTV DNA in patients with liver disease was 21.9% (107/489). In terms of clinical classification, acute hepatitis (AH) was the most common type of TTV infection, accounting for 75% (12/16), significantly higher than 13% (2/15) of overlap HBV infection (x 2 = 11.9 (P <0.01), while those with overlapping infections were mostly chronic hepatitis (CH), accounting for 67% (10/15), significantly higher than those in those infected alone (3/16) ). CONCLUSION: TTV alone manifests itself as acute hepatitis. The effect of overlapping HBV infection on the disease is insignificant, suggesting TTV has certain pathogenicity.