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目的为探讨血清β＿２－微球蛋白（β＿２－Ｍ）与肝炎组织学变化的关系，对肝炎患者血清β＿２－Ｍ含量与肝炎组织学变化进行对比分析。方法甲ＲＩＡ法测定各型肝炎１６７例血清β＿２－Ｍ含量，其中１１０例同时做肝活检，按照Ｋｎｏｄｅｌｌ肝组织炎症活动指数标准记分。结果与正常人比较，各型肝炎患者血清β＿２－Ｍ均明显升高，以ＡＨ、ＣＡＨ及ＰＨＬＣ更为显著（Ｐ＜０．０５～０．０１）。血清β＿２－Ｍ水平与肝细胞坏死及门管区炎症程度密切相关，而与肝纤维化程度无相关性。结论血清β＿２－Ｍ是反映肝实质炎症性质有价值的血清学指标。
Objective To investigate the relationship between the serum β_2-microglobulin (β_2-M) and the histological changes of hepatitis and to compare the serum β_2-M level with hepatitis histology in patients with hepatitis. Method A RIA was used to determine the serum levels of β_2-M in 167 patients with various types of hepatitis. 110 patients underwent liver biopsy at the same time and scored according to Knodell’s index of inflammatory activity index. Results Compared with normal controls, the serum levels of β_2-M in all kinds of hepatitis patients were significantly increased, especially in AH, CAH and PHLC (P <0.05-0.01). Serum β_2-M levels are closely related to the degree of hepatocellular necrosis and portal inflammation, but not to the degree of liver fibrosis. Conclusions Serum β_2-M is a valuable serological marker reflecting the nature of hepatic parenchymal inflammation.