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目的观察胰岛素与格列美脲分别联合二甲双胍治疗2型糖尿病的临床疗效差异。方法将204例2型糖尿病患者,随机分为试验组和对照组各102例。试验组患者选用胰岛素联合二甲双胍治疗,对照组患者选用格列美脲联合二甲双胍治疗。比较2组患者治疗后的临床效果。结果治疗后2组患者的空腹血糖(FPG)、餐后2h血糖(2h PG)、糖化血红蛋白(Hb A1c)检测值均明显下降,空腹C肽(FCP)及餐后2h C肽(2h CP)有所增加,且试验组降低或升高幅度大于对照组,差异均有统计学意义(P<0.05)。2组患者的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)明显下降,高密度脂蛋白胆固醇(HDL-C)则明显升高,且试验组降低或升高幅度大于对照组,差异均有统计学意义(P<0.05)。结论胰岛素联合二甲双胍治疗效果优于格列美脲联合二甲双胍的治疗效果,安全性更高,能够有效缓解患者的病症。
Objective To observe the clinical efficacy of insulin and glimepiride combined with metformin in the treatment of type 2 diabetes mellitus. Methods Totally 204 patients with type 2 diabetes were randomly divided into experimental group and control group of 102 cases. Patients in the test group were treated with insulin plus metformin, and patients in the control group were treated with glimepiride and metformin. The clinical effects of two groups were compared. Results After treatment, the fasting plasma glucose (FPG), postprandial 2h PG, Hb A1c were significantly decreased in both groups (P <0.05). The fasting C peptide (FCP) and postprandial 2h C peptide Increased, and the experimental group decreased or increased more than the control group, the difference was statistically significant (P <0.05). The levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) were significantly decreased and HDL-C was significantly increased in the two groups (P <0.05). The difference was statistically significant (P <0.05). Conclusion The combination of insulin and metformin is better than glimepiride combined with metformin in the treatment of patients with higher safety and can effectively alleviate the patient’s illness.