论文部分内容阅读
目的 观察动物皮肤接触克林霉素磷酸酯-过氧苯甲酰凝胶后有无皮肤刺激、皮肤过敏等反应,为临床安全用药提供依据。 方法 皮肤刺激试验,对家兔完整皮肤和破损皮肤进行单次或多次涂抹0 02g/cm2 的克林霉素磷酸酯-过氧苯甲酰凝胶,单次涂抹和多次涂抹分别为 1d和连续 7d(1 次/d)涂抹,观察涂抹部位有无红斑和水肿等刺激反应情况。皮肤过敏试验,豚鼠每只每周皮肤涂抹0 2g的克林霉素磷酸酯-过氧苯甲酰凝胶1次,连续3周,于首次涂药后的第28 d皮肤给药进行攻击,观察涂抹部位有无红斑和水肿等过敏反应情况。 结果 末见动物发生红斑、水肿等刺激反应和过敏反应。 结论 该药无刺激性及过敏性,具有良好的皮肤用药安全性。
Objective To observe whether skin irritation, skin allergy and other reactions after exposure to clindamycin phosphate - benzoyl peroxide gel in animal skin provide evidence for clinical safety. Methods The skin irritation test was carried out on the whole skin and the damaged skin of rabbits. The clindamycin phosphate-benzoyl peroxide gel was smeared at 0 02 g / cm2 for one or more times, And continuous 7d (1 / d) smear, smear the site to see whether erythema and edema and other stimulus response. Skin allergy test: guinea pigs were treated with 0 2 g clindamycin phosphate-benzoyl peroxide gel once a week for 3 consecutive weeks. The guinea pigs were challenged with 28 d dosing of the skin after the first application, Observed smear sites with erythema and edema and other allergic reactions. The results do not see animal erythema, edema and other irritating reactions and allergic reactions. Conclusion The drug is non-irritating and allergic, with good skin drug safety.