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乙胺碘呋酮用于严重的室性及室上性心律失常疗效显著。长期应用可引起肺间质纤维化。本文报告2例。 例 1,男性,64岁。5年前因阵发性室性心动过速应用乙胺碘呋酮5年,维持量200 mg隔日1次,总量172.6g。血清乙胺碘呋酮浓度1ng/ml,用药4.5年出现劳力性气短,心脏及肝脏逐渐扩大。用药5年气喘加重,胸相显示肺间质纤维化,心电图电轴右偏。患者死于呼吸衰竭及心力衰竭。病人未曾用激素治疗。
Amiodarone is used in the treatment of severe ventricular and supraventricular arrhythmias. Long-term use can cause pulmonary interstitial fibrosis. This article reports 2 cases. Example 1, male, 64 years old. 5 years ago due to paroxysmal supraventricular tachycardia with amiodarone 5 years to maintain the amount of 200 mg every other day, a total of 172.6g. Serum amiodarone concentration of 1ng / ml, medication 4.5 years of labor-induced shortness of breath, heart and liver gradually expanded. Asthma increased medication for 5 years, the chest showed pulmonary interstitial fibrosis, electrocardiogram axis deviation. The patient died of respiratory failure and heart failure. The patient has not been treated with hormones.