论文部分内容阅读
[目的]观察丽珠胃三联治疗海员消化性溃疡的疗效及幽门螺杆菌(Hp)根除率。[方法]Hp阳性的海员消化性溃疡86例,随机分2组:治疗组46例,给予丽珠胃三联,即枸橼酸铋钾110 mg,4次/d,替硝唑0.5 g,2次/d,克拉霉素0.25 g,2次/d;对照组40例,给予达克普隆30 mg,阿莫西林1.0 g,甲硝唑400 mg,均2次/d。2组均连续治疗。7 d停药4周后复查电子胃镜及14C-尿素呼气试验检测其Hp阴转率。[结果]治疗组和对照组溃疡治疗有效率分别为89.1%及90.0%;Hp根除率为87.0%和90.0%;疼痛缓解率为84.7%和85.0%;2组差异均无统计学意义(P>0.05)。治疗组的腹痛消失时间、症状消失率较对照组快,但差异均无统计学意义(P>0 05)。[结论]丽珠胃三联能有效根除Hp,对海员消化性溃疡有较高的治愈率和症状缓解率,服用方便,不良反应小。
[Objective] To observe the curative effect of Livzon stomach triple therapy on peptic ulcer and the eradication rate of Helicobacter pylori (Hp). [Method] 86 Hp-positive seafarers with peptic ulcer were randomly divided into 2 groups: 46 cases in the treatment group, which were given Livzon triple therapy with 110 mg bismuth potassium citrate 4 times daily and tinidazole 0.5 g 2 Times / d, clarithromycin 0.25 g, 2 times / d; control group of 40 patients, given daclopron 30 mg, amoxicillin 1.0 g, metronidazole 400 mg, were 2 times / d. 2 groups were treated continuously. 7 d withdrawal 4 weeks after the review electronic endoscopy and 14 C-urea breath test to detect the Hp negative conversion rate. [Results] The effective rates of treatment of ulcer in treatment group and control group were 89.1% and 90.0% respectively; the eradication rate of Hp was 87.0% and 90.0%; the pain relief rate was 84.7% and 85.0% respectively; there was no significant difference between the two groups > 0.05). The disappearance of abdominal pain and the disappearance of symptoms in the treatment group were faster than those in the control group, but the differences were not statistically significant (P> 0.05). [Conclusion] Livzon triple therapy can effectively eradicate Hp and has higher cure rate and symptom relief rate for peptic ulcer of seafarers. It is convenient to take and the adverse reaction is small.