论文部分内容阅读
目的探讨IL-18基因遗传多态与口腔癌发病的关系。方法检测IL-18基因rs1946519、rs187238和rs549908位点基因型在364例口腔癌患者(A组)和778例健康人群(B组)的分布,比较不同基因型与口腔癌发病的相关性。结果 A组rs549908位点AC和AC+CC基因型分布均低于B组(20.9%vs.28.0%和21.4%vs.31.6%)(P<0.05)。A组GGC单倍型分布低于B组(3.3%vs.6.3%)(P<0.05)。A组rs549908位点AA和AC+CC基因型患者血清IL-18水平高于B组[(473.61±110.76)pg/ml vs.(110.93±50.39)pg/ml和(489.00±108.65)pg/ml vs.(110.74±49.17)pg/ml](P<0.01)。结论 IL-18基因遗传多态与口腔癌的发病风险存在关联。
Objective To investigate the relationship between IL-18 gene polymorphism and the pathogenesis of oral cancer. Methods The genotypes of rs1946519, rs187238 and rs549908 of IL-18 gene were detected in 364 oral cancer patients (group A) and 778 healthy people (group B), and the correlation between different genotypes and the incidence of oral cancer was compared. Results The distribution of AC and AC + CC genotypes of rs549908 in group A were lower than those in group B (20.9% vs.28.0% and 21.4% vs.31.6%, P <0.05). The distribution of GGC haplotype in group A was lower than that in group B (3.3% vs.6.3%) (P <0.05). Serum levels of IL-18 in patients with AA and AC + CC genotypes in group A at rs549908 were significantly higher than those in group B [(473.61 ± 110.76) pg / ml vs. (110.93 ± 50.39) pg / ml and (489.00 ± 108.65) pg / ml vs. (110.74 ± 49.17) pg / ml] (P <0.01). Conclusion The genetic polymorphism of IL-18 gene is associated with the risk of oral cancer.