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目的:比较大黄虫传统丸剂与超微粉剂对免疫性肝纤维化大鼠模型的药效作用。方法:用猪血清诱导大鼠免疫性肝纤维化模型,将实验动物分为正常组、模型组、传统丸剂组(大黄虫丸,2.7g/kg/d)、超微粉剂组(大黄虫丸,2.0g/kg/d),观察大黄虫丸不同剂型对肝纤维化大鼠肝功能指标、血清纤维化指标、病理组织的影响。结果:与正常组比较,模型组血清各纤维化指标显著升高(P<0.01),肝脏出现典型纤维化表现。与模型组比较,传统丸剂组与超微粉剂组血清各纤维化指标降低(P<0.01),肝纤维化程度减轻,肝组织结构明显改善;与传统丸剂组比较,超微粉剂组血清谷丙转氨酶(ALT)、谷草转氨酶(AST)较低(P<0.05),其余指标无显著性差异。结论:大黄虫传统丸剂与超微粉剂对免疫性肝纤维化均有较好的防治作用,在改善肝功能方面,超微粉剂型优于传统丸剂型。
OBJECTIVE: To compare the pharmacodynamic effects of Rhubarb worm traditional pills and AMD powder on immune hepatic fibrosis in rats. Methods: The rat model of autoimmune liver fibrosis induced by porcine serum was established. The experimental animals were divided into normal group, model group, traditional pill group (2.7g / kg / d), superfine powder group Worm pill, 2.0g / kg / d) to observe the effects of different dosage forms of rhubarb and zoster insects on liver function indexes, serum fibrosis indexes and pathological tissues in rats with hepatic fibrosis. Results: Compared with the normal group, the serum fibrosis index of the model group was significantly increased (P <0.01), and the liver showed typical fibrosis. Compared with the model group, the indexes of serum fibrosis of the traditional pills group and the superfine powder group decreased (P <0.01), the degree of hepatic fibrosis decreased and the hepatic tissue structure improved obviously. Compared with the traditional pills group, Aminotransferase (ALT), aspartate aminotransferase (AST) was lower (P <0.05), the remaining indicators no significant difference. Conclusion: Rhubarb worm traditional pills and superfine powder have better preventive and therapeutic effects on immune liver fibrosis. Superfine powder is better than traditional pills in improving liver function.