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目的:证实脑血管病(CVD)为多基因遗传病,用计算机进行遗传咨询。方法:用计算机推算CVD的相应阈值、遗传度及各级亲属关系发病概率后,按一定计算公式进行数值积累计算。结果:编制了CVD再发风险率程序和遗传咨询表,根据咨询对象提供的家属发病情况,查表可知其再发风险率,复杂家系者,可用再发风险程序,采用实时咨询。结论:本资料显示CVD为多基因遗传病,应用计算机咨询,对再发风险率较大者,重点加强CVD预防。
Objective: To confirm that cerebrovascular disease (CVD) is a polygenic disease with genetic counseling by computer. Methods: Using computer to calculate the corresponding threshold of CVD, degree of heritability and the incidence of kinship at all levels, the numerical calculation was made according to a certain formula. Results: The risk of recurrent risk of CVD and the genetic counseling table were compiled. According to the incidence of family members provided by the counselors, the risk of recurrence was found in the questionnaire, and the risk of recurrence was evaluated by using the real-time counseling. CONCLUSIONS: This data shows that CVD is a polygenic disease with computerized counseling, with a strong risk of recurrent disease with a focus on CVD prevention.