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目的:探究中医结合柳氮磺胺吡啶治疗溃疡性结肠炎的临床治疗效果。方法:采用回顾性分析的方法,将2014年5月~2015年5月期间在我院进行治疗的60例溃疡性结肠炎患者作为本次研究的对象,并将这60例患者按照随机的原则分为干预组与对照组,每组各为30例,对对照组患者给予单纯的柳氮磺胺吡啶进行治疗,对干预组患者则在此基础上进而实行采用中医灌洗液灌肠治疗,对这两组患者的血清IFN-y、IL-4水平以及治疗前后的临床活动指数进行比较分析,同时对患者的治疗效果进行分析。结果:经过治疗,干预组患者的血清IFN-y、IL-4水平与对照组相比差异明显,干预组优于对照组,有统计学意义(P<0.05);干预组与对照组患者的临床活动指数与治疗前相比均得到了提升,且干预组优于对照组(P<0.05),有统计学意义;干预组的总有治疗效率为93.3%,对照组仅为63.4%,差异具有统计学意义(P<0.05)。结论:采用中医灌肠联合柳氮磺胺吡啶对溃疡性结肠炎患者有着明显的治疗效果,能够有效改善患者的临床活动指标以及血清水平,提升治疗效果,可以在临床医学中得以广泛地参考应用。
Objective: To explore the clinical effect of Chinese medicine combined with sulfasalazine in the treatment of ulcerative colitis. Methods: A retrospective analysis of 60 patients with ulcerative colitis treated in our hospital from May 2014 to May 2015 as the object of this study, and these 60 patients according to the randomized principle Divided into the intervention group and the control group, each group of 30 cases, the control group patients given simple sulfasalazine treatment, the intervention group patients on the basis of this and then the use of Chinese medicine lavage enema treatment, this The levels of serum IFN-γ and IL-4 in both groups were compared before and after treatment, and the clinical effect index was analyzed. Results: After treatment, the levels of serum IFN-γ and IL-4 in the intervention group were significantly different from those in the control group, and the intervention group was better than the control group (P <0.05); the intervention group and the control group The clinical activity index was improved compared with that before treatment, and the intervention group was better than the control group (P <0.05), with statistical significance; the total effective rate of the intervention group was 93.3% and that of the control group was only 63.4% Statistically significant (P <0.05). Conclusion: The Chinese medicine enema combined with sulfasalazine has obvious curative effect on patients with ulcerative colitis, which can effectively improve the clinical activity index and serum level of patients and improve the therapeutic effect, which can be widely used in clinical medicine.