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目的探讨晚期贲门癌的安全有效的治疗手段。方法对32例晚期贲门癌患者先进行一次经皮穿刺胃左或腹腔动脉的灌注化疗。然后对贲门癌和周围肿瘤病灶进行放射治疗,DT达60 Gy,生物有效剂量(BED)达72 Gy,随访观察患者临床症状改善情况,并对病灶进行X线、胃镜、CT检查和治疗前后对比。结果所有患者临床症状均有明显改善,影像学检查显示,肿瘤病灶明显缩小,患者生存质量提高,生存时间明显延长。结论动脉插管化疗和放射治疗联合应用治疗晚期贲门癌安全,疗效好,副作用小;动脉插管化疗与放射治疗间隔时间越短,疗效越佳,但全身毒副反应也越大;采取三维适形放疗精度高,并发症少,放射治疗增益比提高,从而能更好地提高晚期贲门癌的治疗效果。
Objective To investigate the safe and effective treatment of advanced cardia cancer. Methods Thirty-two patients with advanced cardiac cancer underwent percutaneous puncture of gastric left or celiac artery. Radiotherapy was performed on cardiac cancer and surrounding tumor lesions. The DT reached 60 Gy and the BED reached 72 Gy. The improvement of clinical symptoms was followed up. The lesions were examined by X-ray, gastroscopy and CT before and after treatment . Results All patients had significant clinical symptoms, imaging examination showed that tumor lesions were significantly reduced, patients with improved quality of life, survival was significantly longer. Conclusion Arterial intubation chemotherapy and radiation therapy combined with the application of advanced cardia cancer safety, good curative effect, side effects; Arterial intubation chemotherapy and radiation therapy shorter intervals, the better the effect, but the more systemic side effects; take three-dimensional fitness Radiotherapy high precision, fewer complications, increased radiation therapy benefit ratio, which can better improve the treatment of advanced cardia cancer.