血清补体蛋白C3是宿主先天性免疫防御补体系统的中心分子,在补体活化的经典途径、替代途径以及甘露聚糖结合凝集途径中均发挥枢纽作用。1996年,Dempsey等[1] 制备了鸡卵溶菌酶(henegglysozyme ,HEL)分别与1～3个小鼠C3d分子融合的偶联蛋白。以此重组抗原免疫小鼠,发现HEL C3d2 Serum complement protein C3 is the central molecule of innate immune defense complement system in host, and plays a pivotal role in the classical pathway of complement activation, alternative pathway and mannan binding and aggregation pathway. In 1996, Dempsey et al [1] prepared a hengglysozyme (hengglysozyme, HEL), respectively, with 1 to 3 mouse C3d molecule fusion coupling protein. Mice were immunized with this recombinant antigen and HEL C3d2 was found