组氨酸三聚体家族蛋白Htp是一类广泛分布于链球菌属的细菌表面蛋白,其氨基酸序列的典型特征是存在多个重复出现且高度保守的组氨酸三聚体基序His-x-x-His-x-His。该家族蛋白在细菌的生理和致病过程中发挥重要功能。本文简要综述了该家族蛋白的发现、结构特征、分类、在细菌致病过程中的作用及其作为潜在的蛋白疫苗侯选分子的最新研究进展。 Histidine trimer family of proteins Htp is a family of bacterial surface proteins widely distributed in Streptococcus, whose amino acid sequence is typically characterized by the presence of multiple, repetitive and highly conserved histidine trimer motifs His-xx -His-x-His. This family of proteins plays an important role in the physiology and pathogenesis of bacteria. This review summarizes the discovery, structural features, classification of this family of proteins, their role in bacterial pathogenesis and their recent advances as potential protein vaccine candidate molecules.