The thermodynamic properties of Ta metal under high pressure are studied by molecular dynamics simulation. For dislocation-free Ta crystal, all the thermodynamic properties considered are in good agreement with the results from exper-iments or higher level calculations. If dislocations are included in the Ta crystal, it is found that as the dislocation density increases, the hydrostatic pressure at the phase transition point of bcc→hcp and hcp→fcc decreases, while the Hugoniot temperature increases. Meanwhile, the impact pressure at the elastic–plastic transition point is found to depend on the crys-tallographic orientation of the pressure. As the dislocation density increases, the pressure of the elastic–plastic transition point decreases rapidly at the initial stage, then gradually decreases with the increase of the dislocation density.