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用超薄等电聚焦电泳和利凡诺-硫酸亚铁铵样品处理法,分析中国南方11个少数民族共计2121人的血清转铁蛋白C(TfC)亚型多态。结果Tf~(C1),Tf~(C2)和Tf~(Dhi)存在于所有被查群体中,而Tf~B则完全缺乏。在3个群体中发现Tf~(C4),6个群体中发现Tf~(C3),二者的频率都小于0.01。在布依族中发现罕见的TfC4-2型,黎族中发现TfC4-4型,哈尼族中发现TfC4-1型,哈尼族和黎族中分别发现TfC3-2型;另在布依族和彝族中发现TfDChi纯合子。11个少数民族的Tf~(C2)频率变动范围为0.25～0.38,比以前报道的中国汉族群体Tf~(C2)频率为0.18～0.25高得多,特別是白族群体的Tf~(C2)频率已达到世界范围的最高值(0.38)。笔者认为中国南方少数民族Tf~(C2)频率高的原因,除与民族差异有关外,可能还与地理环境气候及人群相对隔离有关。Tf~(C4)虽然在中国人群中出现的频率较低,但似乎支持美印地安人中高频率的Tf~(C4)来源于祖先的蒙古人种这一论点。
Using ultrathin isoelectric focusing electrophoresis and rivanol - ammonium ferrous sulfate sample preparation method, 2121 human serum transferrin C (TfC) isoforms of 11 ethnic minorities in southern China were analyzed. Results Tf ~ (C1), Tf ~ (C2) and Tf ~ (Dhi) were all found in all tested populations, while Tf ~ B was completely absent. Tf ~ (C4) was found in three groups, and Tf ~ (C3) was found in six groups, both of which were less than 0.01. TfC4-2 type was found in Buyi ethnic group, TfC4-4 type was found in Li ethnic group, TfC4-1 type was found in Hani ethnic group, TfC3-2 type was found in Hani ethnic group and Li ethnic group respectively, and TfDChi was found in Buyi ethnic group and Yi ethnic group Homozygous. The frequencies of Tf ~ (C2) in 11 ethnic minorities ranged from 0.25 to 0.38, much higher than the previously reported Tf ~ (C2) frequency of 0.18 ~ 0.25 in Chinese Han population, especially the frequency of Tf ~ (C2) in Bai population Has reached the highest value in the world (0.38). The author believes that the reasons for the high frequency of Tf ~ (C2) in the ethnic minorities in southern China may be related to the relative isolation of geography, environment and population as well as ethnic differences. Tf ~ (C4), though less frequently occurring in the Chinese population, seems to support the argument that the high frequency of Tf ~ (C4) in the Native Americans originates from the ancestral Mongols.