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航天员因失重而产生肌肉萎缩,引起了国内外很多学者的关注,并进行了广泛研究。本文观察尾吊大鼠服用中药后比目鱼肌血流量和肌肉力学特性的变化。实验采用45只SD 品系雄性大鼠,体重240-300g,将鼠按体重分为3组。尾吊大鼠头低位20-25°。三组鼠每天按固定时间分别灌水和强肌Ⅰ、Ⅱ号中药(30g/kg),悬吊15天后,用戊巴比妥钠(4mg/100g)麻醉,用张力、位移传感器测量肌肉力学特性各参数,用标有~(51)Cr 同位素青蛙红血球方法测比目鱼肌的血流量。结果表明:强肌Ⅰ、Ⅱ号中药对尾吊大鼠比目鱼肌血流量、肌肉力学特性有改善作用。其中强肌Ⅱ号效果更明显。比目鱼肌的血流量与等长单收缩、强直收缩张力峰值呈正相关,相关系数分别为0.81、0.84。本结果为防护肌肉萎缩措施提供了实验依据。
Astronaut loss of muscle resulting from muscle atrophy, attracted many scholars at home and abroad, and conducted extensive research. In this paper, we observed the changes of soleus muscle blood flow and muscle mechanics in tail-suspended rats. Forty-five male SD rats, weighing 240-300 g, were divided into three groups according to body weight. Tail hanging rat head low 20-25 °. Three groups of rats were infused with strong muscle Ⅰ and Ⅱ Chinese herbs (30g / kg) every day for a fixed period of time. After being suspended for 15 days, they were anesthetized with sodium pentobarbital (4mg / 100g) and their mechanical properties were measured by tension and displacement sensors Various parameters, with ~ (51) Cr isotopes of the frog red blood cells measured soleus muscle blood flow. The results showed that Chinese myelodysplastics I and II could improve the blood flow and muscular mechanical properties of soleus muscle of tail-suspended rats. One strong muscle Ⅱ effect is more obvious. Soleus muscle blood flow and unidirectional unidirectional systolic and tonic systolic tension peak was positively correlated, the correlation coefficients were 0.81,0.84. This result provides an experimental basis for the protection of muscle atrophy measures.