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人群中异喹胍羟化代谢分布呈多态性,并具有家族遗传性。异喹胍羟化代谢缺陷具有常染色体隐性遗传方式的特点,其代谢缺陷频发率存在着种族差异。它主要是由于肝微粒体细胞色素 P_(450)。羟化同功酶功能缺陷的结果。
Quinquonidine hydroxylase metabolism in the population was polymorphic and family heritability. The mechanism of hydroxyquinoloid metabolism is characterized by autosomal recessive inheritance. There are racial differences in the frequency of metabolic defects. It is mainly due to hepatic microsomal cytochrome P_ (450). Hydroxylated isozyme dysfunction results.