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目的:本文通过研究白介素23受体(IL-23R)基因多态性与扩张型心肌病(DCM)的相关性,探讨DCM患者的免疫遗传学发病机制.方法:采用PCR-RFLP方法测定DCM患者和正常对照者IL-23R基因rs7517847位点的单核苷酸多态性.用卡方检验比较病例组与对照组之间基因型频率和等位基因频率的统计学差异。结果:IL-23R基因rs7517847位点单核苷酸多态基因型和等位基因频率在DCM组与正常对照组之间无差异。结论:本研究未发现IL-23R基因rs7517847位点多态性与DCM相关。
OBJECTIVE: To investigate the pathogenesis of DCM in patients with DCM by studying the association between interleukin-23 receptor (IL-23R) polymorphism and DCM.Methods: PCR-RFLP was used to determine the risk of DCM And rs7517847 locus of IL-23R gene in normal controls.Data was analyzed by Chi-square test to compare the difference of genotype frequency and allele frequency between case group and control group. Results: There was no difference in genotype and allele frequencies of SNP rs7517847 at IL-23R between DCM group and normal control group. Conclusion: This study did not find IL-23R gene rs7517847 polymorphism associated with DCM.