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目前认为消化性溃疡的病因是由精神因素及各种物理化学刺激,使防御因子减弱,攻击因子增强,H~+逆扩散所致,为此,治疗上寻找能增强防御因子,抑制攻击因子,防止H~+逆扩散的药物。一、甲腈咪胍(Cimetidine) 因组织胺能促进胃液分泌,它存在于胃粘膜细胞H_2受体(H_2—R),对此,设想存在着能作用于H_2—R,与组织胺互相竞争,而达到抑制胃液分泌的药物,其构造与组织胺类似。1975年英国Brimblecombe合成甲腈咪胍。它具有强力抗胃液分泌作用,副作用又小,受到重视。
At present, the cause of peptic ulcer is thought to be caused by the mental factors and various physicochemical stimuli, which make the defensive factor weakened, the attack factor increased, and H ~ + reverse diffused. Therefore, we should look for ways to enhance the defense factor, inhibit the attack factor, Prevent the proliferation of H ~ + drugs. First, Cimetidine due to histamine can promote gastric secretion, which exists in the gastric mucosal H_2 receptor (H_2R), which, it is assumed that there is a role in H_2-R, and histamine competed with each other , And to achieve inhibition of gastric secretion of drugs, its structure and histamine similar. 1975 British Brimblecombe synthesis of cimetidine. It has a strong anti-gastric secretion, side effects and small, attention.