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目的 进一步证实“新生儿缺氧缺血性脑病 (HIE)治疗方案 (试行稿 )”的疗效。方法 统计国内 5 4所医院 114 5份HIE病例的临床资料 ,所有病例均按上述治疗方案至少治疗 1个疗程 ,并随访至少 6个月。结果 HIE患儿总的预后不良率为 5 15 % ,其中重度预后不良率为 2 0 8% ,中度为 2 2 2 % ,轻度为 0 ,与第 1次多中心治疗比较 ,预后不良率略有下降。结论 上述治疗方案的疗效是肯定的 ,经得起大样本的重复试验 ,新生儿期后治疗可明显改善重度HIE的预后。
Objective To further confirm the “neonatal hypoxic-ischemic encephalopathy (HIE) treatment program (trial draft)” effect. Methods The clinical data of 114 5 HIE cases were collected from 54 hospitals in China. All cases were treated for at least one course of treatment according to the above treatment plan and followed up for at least 6 months. Results The overall rate of adverse prognosis in children with HIE was 51.5%. The rate of severe dysplasia was 20.8%, the moderate was 22.2% and the mild was 0. Compared with the first multicentre, the poor prognosis Slight decline. Conclusion The curative effect of the above treatment is affirmative and can stand the test of large sample. The treatment after neonatal period can obviously improve the prognosis of severe HIE.