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目的:探讨铜绿假单胞菌耐药率与9种常用抗菌药使用量的相关性。方法:采用回顾性调查方法,分别统计我院2003～2007年铜绿假单胞菌的耐药率及9种常用抗菌药的用药频度(DDDs),用直线回归方法对耐药率与用药频度进行相关性分析。结果:5年来铜绿假单胞菌对9种抗菌药的耐药率全部呈现增长态势,环丙沙星的耐药率最高。耐药率与用药频度的相关性显示,铜绿假单胞菌对环丙沙星、头孢他啶的耐药率与哌拉西林的用量呈显著负相关。结论:铜绿假单胞菌耐药率的上升趋势与抗菌药的大量使用有一定关系,临床应根据细菌耐药性合理选择抗菌药,以减少耐药菌株的产生。
Objective: To investigate the correlation between the rate of drug resistance of Pseudomonas aeruginosa and the usage of 9 commonly used antibiotics. Methods: We retrospectively investigated the drug resistance rate of Pseudomonas aeruginosa in our hospital from 2003 to 2007 and the frequency of drug use (DDDs) of 9 commonly used antibacterials in our hospital. Degree correlation analysis. Results: The resistance rates of Pseudomonas aeruginosa to 9 kinds of antimicrobial agents all showed an increasing trend over the past five years, and the drug resistance rate of ciprofloxacin was the highest. The correlation between the drug resistance rate and frequency of drug use showed that the drug resistance rate of Pseudomonas aeruginosa to ciprofloxacin and ceftazidime was negatively correlated with the dosage of piperacillin. Conclusion: The upward trend of drug resistance rate of Pseudomonas aeruginosa is related to the extensive use of antimicrobial agents. Antibiotics should be selected reasonably according to the drug resistance of bacteria to reduce the production of resistant strains.