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目的:观察胃内注入活性炭和生大黄对急性口服有机磷农药中毒的毒物清除作用。方法:将50例急性口服有机磷农药重度中毒患者随机分为治疗组25例(活性炭吸附毒物和生大黄导泻)和对照组25例(未用活性炭,用甘露醇导泻)。两组患者均进行急性有机磷农药中毒常规治疗,观察两组患者阿托品化时间、抢救成功率和住院时间的差异及有无反跳、中间综合征发生。结果:治疗组阿托品化时间、住院时间与对照组比较有明显差异(P<0.01)。无反跳、中间综合征发生,抢救成功率有一定提高。结论:活性炭和生大黄联合治疗急性口服有机磷农药中毒,较传统洗胃导泻法更能有效清除进入体内的有机磷农药,能缩短患者阿托品化时间和住院时间,减少反跳、中间综合征发生,提高抢救成功率,改善患者预后。
Objective: To observe the scavenging effects of activated charcoal and rhubarb on the poisoning of acute oral organophosphorus pesticide poisoning. Methods: Fifty patients with severe oral organophosphorus pesticide poisoning were randomly divided into treatment group of 25 cases (activated carbon adsorption poison and rhubarb catharsis) and control group of 25 cases (without activated carbon, mannitol catharsis). Two groups of patients were routinely treated with acute organophosphorus pesticide poisoning. The difference of atropisol time, rescue success rate, length of hospital stay and whether there was rebound or intermediate syndrome were observed in the two groups. Results: There was a significant difference between the treatment group and the control group in atropisol time and hospitalization time (P <0.01). No rebound, intermediate syndrome occurred, the success rate of rescue has a certain increase. Conclusion: Activated charcoal and rhubarb combined treatment of acute oral organophosphorus pesticide poisoning, compared with the traditional gastric lavage and catharsis method is more effective in removing organophosphorus pesticide into the body, can shorten the patients atropine and hospitalization time, reduce rebound, intermediate syndrome Occur, improve the success rate of rescue, improve patient’s prognosis.