锂盐广泛用于治疗情感性疾病。近来,接受锂盐治疗的高龄患者日渐增加,其中一些人可能患有心血管疾病而需洋地黄类药物治疗。Naylor等曾报告锂盐及地高辛对细胞膜上Na~+ -K~+ -ATP酶有相反作用,即锂盐增加躁郁症患者Na~+ -K~+ -ATP酶活性,而地高辛则抑制细胞膜上该酶的活性。许多临床现象和生物化学方面的证据也提示地高辛和锂盐存在相互作用。因此,Chambers等认 Lithium salts are widely used to treat affective disorders. Recently, the number of elderly patients receiving Lithium salt treatment is on the rise. Some of them may have cardiovascular disease and need digitalis treatment. Naylor et al. Reported that lithium salt and digoxin have the opposite effect on Na ~ + -K ~ + -ATPase in the cell membrane, that is, lithium salt increases Na ~ + -K ~ + -ATPase activity in patients with bipolar disorder, Xin inhibits the activity of the enzyme on the cell membrane. Many clinical and biochemical evidence also suggests that digoxin and lithium salts interact. As a result, Chambers et al