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目的探讨滤泡辅助性T淋巴细胞(Tfh)检测对自身免疫性甲状腺疾病(AITD)的诊断意义。方法选取2014年5月至2016年5月接受治疗的AITD患者80例,其中桥本氏甲状腺炎(HT,为HT组)与Graves病(GD,为GD组)患者各40例,并选择同期进行健康体检人群40例(为对照组),检测三组人群的Tfh水平的变化。结果与对照组相比,HT组及GD组的Tfh/CD4+细胞比例明显上升(P<0.05),但HT组及GD组的Tfh/CD4+细胞比例未见统计学意义(P>0.05);HT组Tfh/CD4+细胞与血浆Tg-Ab及TPO-Ab水平呈正相关,GD组Tfh/CD4+细胞与血浆TSHR-Ab及TPO-Ab水平呈正相关(P均<0.05)。结论在AITD患者中可检测到Tfh细胞比例增加,且其比例与TSHR-Ab、Tg-Ab及TPO-Ab水平呈正相关,提示Tfh细胞在AITD的发病中具有一定作用。
Objective To investigate the diagnostic value of follicular helper T lymphocyte (Tfh) in the diagnosis of autoimmune thyroid disease (AITD). Methods A total of 80 patients with AITD who were treated from May 2014 to May 2016 were enrolled in this study. Forty patients with Hashimoto’s thyroiditis (HT, HT group) and Graves’ disease (GD, GD group) Forty healthy subjects were selected as control group, and Tfh levels in three groups were tested. Results Compared with the control group, the proportion of Tfh / CD4 + cells in HT group and GD group was significantly increased (P <0.05), but there was no significant difference in the proportion of Tfh / CD4 + cells between HT group and GD group (P> 0.05) Tfh / CD4 + cells were positively correlated with plasma Tg-Ab and TPO-Ab levels. There was a positive correlation between Tfh / CD4 + cells and plasma TSHR-Ab and TPO-Ab levels in GD group (all P <0.05). Conclusion The proportion of Tfh cells detected in AITD patients is increased, and its proportion is positively correlated with TSHR-Ab, Tg-Ab and TPO-Ab levels, suggesting that Tfh cells play a role in the pathogenesis of AITD.