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近年来,肠源性内毒素血症(intestinal endotoxemia,IETM)与肝病的关系日益受到重视.临床观察表明,各种急、慢性肝炎、肝硬变和重型肝炎患者内毒素血症(endotoxemia,ETM)发生率有不同程度升高.内毒素与肝损害之间存在着密切的关系.二者可互为因果,从而对肝病的发生发展产生重要影响.特别是内毒素作用于肝脏后,引起多种细胞因子分泌与释放,导致肝脏损害进一步加重,甚至出现黄疸、出血、肾功能衰竭与肝性脑病等肝功能衰竭临床综合征.
In recent years, the relationship between intestinal endotoxemia (IETM) and liver disease has been paid more and more attention.Clinical observations show that endotoxemia (ETM) in patients with acute and chronic hepatitis, cirrhosis and severe hepatitis ) Have different degrees of increase in endotoxin and liver damage there is a close relationship between the two can each cause and effect, which have a significant impact on the occurrence and development of liver disease, especially after endotoxin in the liver, causing more Secretion and release of cytokines, leading to further aggravate liver damage, and even clinical syndromes of jaundice, bleeding, renal failure and hepatic encephalopathy and other liver failure.