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目的:探讨不同前列腺标本中病变类型特点。方法:收集前列腺标本3 465例,比较穿刺活检(NB)、经尿道前列腺切除(TURP)以及前列腺切除(PC)中不同病变的差异。结果:良性前列腺增生、前列腺腺癌、导管癌、高级别前列腺上皮内瘤变(PIN)、非典型小腺体增生、非典型腺瘤样增生以及其他病变在NB标本中分别占54.6%、38.8%、0.6%、1.4%、1.9%、0.4%以及2.2%,在TURP中分别占93.4%、4.8%、0.3%、0.6%、0.1%、0以及0.6%,在PC中分别占76.4%、19.0%、1.0%、0、0.1%、1.4%以及2.0%。良性前列腺增生在TURP标本中所占比例显著高于NB和PC(P<0.05);前列腺腺癌、高级别PIN以及非典型小腺体增生在NB中所占比例高于TURP和PC(P<0.05);非典型腺瘤样增生在PC中所占比例高于NB和TURP(P<0.05)。结论:前列腺良性增生和前列腺腺癌是三种前列腺标本中最常见的病变;高级别PIN在NB中较多见,病理学报告应该标准化;非典型小腺体增生在NB中较多见,该诊断较为复杂,认识还需要进一步提高;非典型腺瘤样增生在PC中较为常见。
Objective: To investigate the different types of lesions in prostate specimens. Methods: A total of 3 465 prostate specimens were collected. The differences of different lesions in biopsy (NB), transurethral resection of the prostate (TURP) and prostatectomy (PC) were compared. Results: Benign prostatic hyperplasia, prostatic adenocarcinoma, ductal carcinoma, high grade prostatic intraepithelial neoplasia (PIN), atypical gonadal hyperplasia, atypical adenomatous hyperplasia and other lesions accounted for 54.6% and 38.8 Accounting for 93.4%, 4.8%, 0.3%, 0.6%, 0.1%, 0% and 0.6% in TURP, accounting for 76.4% in PC, 19.0%, 1.0%, 0,0.1%, 1.4% and 2.0%. The proportion of benign prostatic hyperplasia in TURP specimens was significantly higher than that of NB and PC (P <0.05). The proportion of prostate adenocarcinoma, high-grade PIN and atypical gonad hyperplasia in NB was higher than that in TURP and PC (P < 0.05). The proportion of atypical adenomatous hyperplasia in PC was higher than that of NB and TURP (P <0.05). Conclusions: Benign prostatic hyperplasia and prostatic adenocarcinoma are the most common lesions in three kinds of prostate specimens. High-grade PIN is more common in NB and pathological reports should be standardized. Atypical gland hyperplasia is more common in NB, Diagnosis is more complex, awareness needs to be further improved; atypical adenomatous hyperplasia is more common in PC.