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目的:探讨中药软肝冲剂对大鼠实验性肝纤维化的防治作用及对慢性肝炎(中、重度)、肝硬变代偿期患者的临床疗效。方法:①实验研究:将20只Wistar大鼠分成造模组和软肝组,每组10只。均用人血清白蛋白与弗氏不完全佐剂等量混合的乳化液造模,在两组大鼠皮下多处注射乳化液0.5ml/次,共5次,前2次间隔时间为14天,后3次间隔7天,末次注射7天
Objective: To investigate the preventive and therapeutic effects of Ruangan Gangan Granules on experimental hepatic fibrosis in rats and the clinical efficacy of patients with chronic hepatitis (middle and severe) and cirrhosis. Methods: 1 Experimental study: 20 Wistar rats were divided into model group and soft liver group, 10 in each group. All patients were modeled with human serum albumin mixed with Freund’s incomplete adjuvant. The rats were injected subcutaneously with multiple injections of 0.5 ml each time for 5 times. The interval between the previous two injections was 14 days. After 3 intervals of 7 days, the last injection is 7 days