近年来,有机合成化学家对制备高纯度光学活性化合物极感兴趣。1984年,美国Purdue大学Brown教授等曾报道获得高纯度光学活性化合物的简单方法。该方法是以手性试剂单异松蒎烯基硼烷(mono-isopinocampheylborane,IpcBH_2)1,与二取代、三取代烯烃2发生不对称诱导的硼氢化反应,此时可引入一个或二个手性中心。由于主、副产物结晶性质有明 In recent years, organic synthesis chemists are extremely interested in preparing high purity optically active compounds. In 1984, Brown, Purdue University, USA, etc. have reported a simple method to obtain high purity optically active compounds. The method uses the asymmetric induced hydroboration reaction between the mono-isopinocampheylborane (IpcBH_2) 1 and the disubstituted and trisubstituted alkenes 2, in which case one or two hands can be introduced Sex center. Due to the main, by-product crystalline nature of bright