磷脂酰胆碱(PC)的生物合成已如前述,其主要合成道路是以胆碱为原料,由ATP提供磷酸形成磷酸胆碱,再由CTP:磷酸胆碱胞苷转移酶(CT)催化生成CDP-胆碱,后者和二脂酰甘油作用最后生成CP。近年来关于CP生物合成的调节已有不少报道,证明CT是CP合成通路中的限速因子,从表1所列各中间代谢物代谢池的大小,可以明显地看出由CT催化的磷酸胆碱转变成CDP-胆碱的反应,是这条合成通路的瓶颈,限制了合成反应的进行。 Phosphatidylcholine (PC) biosynthesis has been described above, the main synthetic pathway is to use choline as raw material, provided by the phosphate phosphate to form phosphocholine, and then by the CTP: phosphocholine cytidine transaminase (CT) CDP-choline, the latter and the role of ditaloyl glycerol finally generated CP. In recent years, there have been many reports about the regulation of CP biosynthesis. It is proved that CT is a rate limiting factor in the CP synthesis pathway. From the sizes of each intermediate metabolite metabolism pool listed in Table 1, it is obvious that CT-catalyzed phosphoric acid The conversion of choline to CDP-choline is the bottleneck of this synthetic pathway, limiting the progress of the synthesis reaction.