氨基糖甙类抗生素的耳毒性作用机制还不清楚,学说较多,最近又提出这类抗生素与内耳感觉细胞的磷脂类结合而发挥毒性作用,破坏感觉细胞表面的多糖蛋白复合物,阻止耳石膜位移,影响毛细胞换能等机制的新学说。内耳色素与氨基糖甙类抗生素结合,有降低其毒性的作用。在一定条件下受损的毛细胞可以再生。 Aminoglycoside ototoxicity mechanism is unclear, doctrine is more, and recently proposed such antibiotics and inner ear sensory cells phospholipids play a toxic role, damage the sensory cell surface polysaccharide protein complexes to prevent otolith Membrane displacement, affecting the exchange of hair cells and other mechanisms of the new doctrine. Inner ear pigment and aminoglycoside antibiotics, reduce its toxicity. Under certain conditions damaged hair cells can be regenerated.