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筛选２０４名健康成人为免疫对象，分为Ａ、Ｂ两组，分别接种加热灭活和福尔马林灭活的乙肝血源疫苗。每组选用两种剂量（７μｇ，１４μｇ），并于首次免疫后Ｔ１、Ｔ３、Ｔ７、Ｔ１２采血，用Ａｂｂｏｔｔ试剂药上测其抗－ＨＢｓ水平。对加热灭活乙肝血源疫苗进行一年免疫效果对比评价。结果表明：Ｔ３抗－ＨＢｓ阳性率和乙抗－ＨＢｓ滴度＞１００ｍＩＵ／ｍｌ者的比例在两种疫苗组之间无显著性差异。Ｔ７接种加热灭活乙肝疫苗１４μｇ者的抗－ＨＢｓ阳性率（９６．６％）和抗－ＨＢｓ滴度＞１００ｍＩＵ／ｍｌ者的比例（９３．２％）显著高于接种福尔马林灭活疫苗者（８３．３％和７６．２％）。但Ｔ１２两者之间差异消失。随访期间抗－ＨＢｓＧＭＴ两疫苗组之间始终无显著差异。初步证实加热灭活乙肝血源疫苗具有良好的免疫原性。
A total of 204 healthy adults were selected as immunized subjects and divided into A and B groups. Heparin vaccine was inoculated with heat-inactivated and formalin-inactivated HepG2 respectively. Two doses (7μg, 14μg) were selected in each group. Blood samples were taken at T1, T3, T7 and T12 after the first immunization. Anti-HBs level was measured with Abbott reagent. Comparison of the effect of one-year immunization on hepatitis B virus Heparin inactivated by heat. The results showed that there was no significant difference in the proportion of positive anti-HBs T3 and anti-HBs titer> 100 mIU / ml between the two vaccine groups. The positive rate of anti-HBs (96.6%) and anti-HBs titer> 100mIU / ml (93.2%) in T7 vaccinated with heat-inactivated hepatitis B vaccine were significantly higher than those inoculated with formalin Vaccines (83.3% and 76.2%). But the difference between T12 disappears. There was no significant difference between the two anti-HBsGMT vaccine groups during follow-up. Preliminary confirmed heat-inactivated hepatitis B vaccine has good immunogenicity.