婴幼儿持续高胰岛素血症性低血糖症是婴幼儿持续性低血糖症最常见病因之一。近年来,婴幼儿持续高胰岛素血症性低血糖症的分子发病机制研究有了显著的进展。根据不同的受累基因,可将婴幼儿持续高胰岛素血症性低血糖症大致分为5型,但仍有约半数患者仍未发现致病基因。 Persistent hyperinsulinemic hypoglycemia in infants and young children is one of the most common causes of persistent hypoglycemia in infants and young children. In recent years, infants and young children with persistent hyperinsulinemic hypoglycemia molecular pathogenesis research has made significant progress. According to different genes involved, persistent hyperinsulinemic hypoglycemia in infants and young children can be roughly divided into 5 types, but about half of the patients still do not find pathogenic genes.