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目的:观察黄芪、丹参注射液对异丙肾上腺素致心肌缺血大鼠血清、心肌组织中超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量的影响。方法:60只大鼠随机分为空白对照组、模型组、黄芪注射液组、丹参注射液组,黄芪、丹参注射液联用组,共5组;除空白对照组外,其余各组给药14天后采用注射异丙肾上腺素诱发大鼠心肌缺血损伤模型,检测各组大鼠血清及心肌组织中SOD活性及MDA含量。结果:与空白对照组比较,模型组大鼠血清和心肌组织中的SOD活性降低、MDA含量升高(P<0.05),黄芪注射液组、丹参注射液组大鼠血清和心肌组织中SOD活性与模型组比较均升高(P<0.05)、MDA含量与模型组比较均降低(P<0.05),黄芪、丹参注射液联用组血清和心肌组织中SOD活性、MDA含量与模型组比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。结论:黄芪、丹参注射液可通过调节自由基代谢水平而显著改善大鼠心肌缺血,二者联合使用效果更佳。
Objective: To observe the effects of Astragalus membranaceus and Salvia miltiorrhiza on the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in serum and myocardium of rats with isoproterenol-induced myocardial ischemia. Methods: 60 rats were randomly divided into blank control group, model group, Astragalus injection group, Salvia injection group, Astragalus, Salvia injection group, a total of 5 groups; except for the blank control group, the other groups were administered Fourteen days later, isoproterenol was used to induce myocardial ischemia in rats. The activities of SOD and MDA in serum and myocardium of rats in each group were measured. Results: Compared with the blank control group, SOD activity and MDA content in the serum and myocardial tissue of rats in the untreated group were significantly decreased (P <0.05). SOD activity in the serum and myocardial tissue of the astragalus mongholicus injection group and the Salvia miltiorrhiza injection group Compared with the model group, the content of MDA and the content of MDA decreased (P <0.05), the activities of SOD and the content of MDA in the serum and myocardium of Astragalus mongholicus and Salvia miltiorrhiza injection group were significantly lower than those of model group (P <0.05) The difference was significant or very significant (P <0.05, P <0.01). Conclusion: Astragalus membranaceus and Salvia miltiorrhiza injection can significantly improve myocardial ischemia in rats by regulating the level of free radical metabolism, and their combination effect is better.