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目的探讨原发性高血压患者血小板压积(thrombocytocrit,PCT)与总胆固醇(total cholesterol,TC)的相关性。方法原发性高血压患者204例为观察组,208例非原发性高血压患者为对照组,比较2组血脂、血小板相关参数以及体质量指数、年龄、性别等指标,分析PCT与TC的相关性。结果观察组三酰甘油[(1.93±0.99)mmol/L]、TC[(4.65±0.74)mmol/L]、载脂蛋白B[(1.08±0.29)g/L]、PCT[(0.36±0.12)%]、体质量指数[(27.75±3.37)kg/m2]、年龄[(54.75±10.42)岁]高于对照组[(1.40±1.23)mmol/L、(4.40±0.78)mmol/L、(0.97±0.28)g/L、(0.25±0.05)%、(23.96±3.18)kg/m2、(47.27±8.63)岁](P<0.05),高密度脂蛋白胆固醇[(1.24±0.32)mmol/L]、载脂蛋白A1[(1.33±0.15)g/L]低于对照组[(1.36±0.41)mmol/L、(1.37±0.19)g/L](P<0.05),观察组男性比例(59.31%)高于女性(40.69%),且高于对照组男性比例(26.92%),差异均有统计学意义(P<0.01);校正年龄、性别因素后,观察组PCT与TC具有相关性(r=0.142,P=0.042)。结论原发性高血压患者PCT与TC呈正相关,胆固醇水平升高以及血小板活化增加可能是原发性高血压发生、发展的重要因素。
Objective To investigate the correlation between thrombocytocrit (PCT) and total cholesterol (TC) in patients with essential hypertension. Methods 204 patients with essential hypertension were observed and 208 patients with non-essential hypertension as control group. The levels of serum lipids, platelets, body mass index, age and gender were compared between the two groups. The levels of PCT and PCT Correlation. Results The levels of triglyceride (1.93 ± 0.99 mmol / L), TC [(4.65 ± 0.74) mmol / L], apolipoprotein B (1.08 ± 0.29) g / L and PCT [(0.36 ± 0.12) ) Were significantly higher than those in control group [(1.40 ± 1.23) mmol / L, (4.40 ± 0.78) mmol / L, (0.97 ± 0.28) g / L, (0.25 ± 0.05)%, (23.96 ± 3.18) kg / m2 and (47.27 ± 8.63) / L], and the level of apolipoprotein A1 (1.33 ± 0.15) g / L was lower than that of the control group (1.36 ± 0.41 mmol / L, 1.37 ± 0.19 g / L, P <0.05) (59.31%) was higher than that of female (40.69%), and higher than that of control group (26.92%), the difference was statistically significant (P <0.01) Correlation (r = 0.142, P = 0.042). Conclusions There is a positive correlation between PCT and TC in patients with essential hypertension. Elevated cholesterol levels and increased platelet activation may be important factors for the occurrence and development of essential hypertension.