目的研究慢性丙型肝炎患者胃、十二指肠粘膜病变，探讨其发病机制．方法对经临床确诊的慢性丙型肝炎患者（简称丙肝组，３６例）与胃肠病患者（胃肠病组，８１例）进行内镜下对比研究．结果丙肝组和胃肠病组的ＰＵ，ＧＥＶ，ＤＩ，ＥＩ的发生率分别为６６７％，４１７％，６９４％，２７８％和３８３％，７４％，２８４％，６２％，二者间有显著性差异（Ｐ＜００１）；而两组的ＣＳＧ，ＥＧ，ＥＤ发生率分别为１０００％，２８％，２８％和９８８％，１２％，１２％，无统计学差异（Ｐ＞００５）．丙肝组中，活动型肝硬变的ＰＵ，ＤＩ，ＥＩ发生率（分别为８６７％，８６７％，５３３％）显著高于慢性肝炎重度和中度（分别为５３３％，５３３％，１３３％和５００％，６６７％，００％）（Ｐ＜００５），与肝炎的严重程度呈正比．同时具有２种以上粘膜病变者，丙肝组（６６７％）显著高于胃肠病组（３８３％，Ｐ＜００１）．肝硬变患者中ＧＥＶ轻中度７例，重度８例，同时具有３种以上粘膜病变者后者（１００％）显著多于前者（７１４％，Ｐ＜００１），且后者粘膜病变程度重于前者．丙肝组中ＨＣＶ单纯感染和ＨＣＶ与ＨＢＶ混合感染者? Objective To study gastric and duodenal mucosal lesions in patients with chronic hepatitis C and to explore its pathogenesis. Methods The clinically diagnosed chronic hepatitis C patients (referred to as hepatitis C group, 36 cases) and gastrointestinal disease patients (gastrointestinal disease group, 81 cases) were compared under endoscopy. Results The incidences of PU, GEV, DI and EI in hepatitis C group and gastrointestinal disease group were 667%, 417%, 694%, 278% and 383%, 74% , 284% and 62%, respectively (P <001). The incidences of CSG, EG and ED in the two groups were 1000% and 28% respectively  8% and 988%, 1  2%, 1  2%, no statistical difference (P> 0  05). The incidences of PU, DI and EI in active cirrhosis (86.7%, 86.7%, 53.3%, respectively) in hepatitis C group were significantly higher than those in severe and moderate chronic hepatitis (533 %, 533%, 133%, 500%, 667%, 00%) (P <005), which were in direct proportion to the severity of hepatitis. In patients with more than two mucosal lesions, the hepatitis C group (66.7%) was significantly higher than the gastrointestinal group (38.3%, P <0.01). In the cirrhotic patients, mild to moderate GEV was found in 7 cases, severe in 8 cases, and those with more than 3 mucosal lesions (100%) were significantly more than the former (714%, P <001) Mucosal lesions are heavier than the former. Hepatitis C group HCV infection and HCV and HBV mixed infection?