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在以往的文献中,作者发现对绝经的晚期乳腺癌患者,切除卵巢的临床治疗效果与雌激素受体(ER)水平有关,特别是当ER浓度超过25fmol/mg时,临床治疗效果最好(81.8%)。这一ER浓度对绝经的晚期乳腺癌患者选择双侧卵巢切除治疗具有最好的手术价值。当ER浓度较低时(5或10fmol/mg),临床治疗效果较差(67～68%)。在本文研究中,作者根据肿瘤组织中不同的ER水平估计存活情况,以期明确治疗效果和存活时间延长是否与高ER水平有关。 71例绝经的晚期乳腺癌患者,年龄35～55岁,平均43.6岁。在卵巢切除时测量ER水平并根据ER浓度分组;低于10fmol/mg为1组,10～25
In previous literature, the authors found that clinical outcomes in ovariectomized patients with advanced breast cancer in menopause are associated with estrogen receptor (ER) levels, especially when the ER concentration exceeds 25 fmol / mg 81.8%). This ER concentration has the best surgical value for the treatment of bilateral ovariectomies in menopausal patients with advanced breast cancer. When the ER concentration is lower (5 or 10 fmol / mg), the clinical effect is poor (67-68%). In this study, the authors estimated survival based on the different ER levels in the tumor tissue in order to determine whether the therapeutic effect and prolongation of survival were associated with high ER levels. 71 cases of menopausal advanced breast cancer patients, aged 35 to 55 years, mean 43.6 years old. ER levels were measured at ovariectomy and grouped according to ER concentration; less than 10 fmol / mg for group 1, 10-25