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缺氧诱导因子-1α(hypoxia-inducible factor-1 alpha,HIF-lα)是近来发现的广泛存在于哺乳动物和人体内的一种缺氧应答调控因子,在调节缺氧诱导的基因表达中起关键性作用。它可调节表达多种靶基因如血管内皮生长因子、促红细胞生成素等,对改善脑缺氧缺血后能量代谢障碍、促进脑血流动力学恢复、抑制兴奋性氨基酸毒性、减少细胞凋亡等起重要作用。通过进一步对HIF-lα及其靶基因的研究,可能为临床治疗脑缺氧缺血性损伤提供了一种新的治疗策略。
Hypoxia-inducible factor-1 alpha (hypoxia-inducible factor-1 alpha) is a recently discovered hypoxia response regulator widely found in mammals and humans that plays an important role in the regulation of hypoxia-inducible gene expression The key role. It can regulate the expression of a variety of target genes such as vascular endothelial growth factor, erythropoietin, etc., to improve energy metabolism disorders after cerebral hypoxia and ischemia, promote cerebral hemodynamic recovery, inhibit excitatory amino acid toxicity and reduce apoptosis Play an important role. Further study of HIF-1α and its target genes may provide a new therapeutic strategy for clinical treatment of cerebral hypoxic-ischemic injury.