未定型结肠炎(indeterminate colitis,IC)最初指炎症性肠病(inflammatory bowel disease,IBD)手术切除标本中难以辨别溃疡性结肠炎(ulcerative colitis,UC)还是克罗恩病(Crohn′s disease,CD)的病例。随着内镜技术的发展,IC的概念逐渐延伸至内镜、病理和外科手术中。与此同时,许多IC患者在病程发展过程中演进为UC或CD。目前血清学辅助检查区分IBD类型的敏感性和特异性较差。因此,IC诊断的确立需从临床表现、影像学特征、内镜下表现及组织学特点等方面综合考虑。 In the beginning, indeterminate colitis (IC) was defined as the presence of ulcerative colitis (UC) or Crohn’s disease in surgically resected specimens of inflammatory bowel disease (IBD) CD) cases. With the development of endoscopic technology, the concept of IC gradually extends to endoscopy, pathology and surgery. In the meantime, many IC patients evolve to UC or CD during their course of disease. Current serological tests to distinguish IBD type sensitivity and specificity of poor. Therefore, the establishment of IC diagnosis from the clinical manifestations, imaging features, endoscopic findings and histological features and other aspects of comprehensive consideration.