以往研究表明,受极低剂量α粒子照射的细胞群体或组织中的遗传损害可存在于未受到照射的细胞(称之为“旁观”细胞)中。为此,对正常人细胞受极低剂量α粒子照射后TP53/CDKN1A信号转导通路的参与进行了研究,并分析了细胞间通讯在受该通路调控的基因表达中的作用。单个α粒子穿透 Previous studies have shown that genetic damage in populations of cells or tissues irradiated with very low doses of alpha particles can be present in unirradiated cells (termed “bystander” cells). Therefore, the participation of TP53 / CDKN1A signal transduction pathway in normal human cells exposed to very low dose of α-particle was studied, and the role of intercellular communication in gene regulation regulated by this pathway was analyzed. Single alpha particle penetration