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目的观察聚乙二醇干扰素α-2a治疗慢性丙型肝炎的不良反应,探讨有效的处理措施。方法回顾性分析我院2011年1月～2012年1月收治的38例慢性丙型肝炎患者的临床资料,所有患者均给予聚乙二醇干扰素α-2a治疗,观察患者治疗期间的不良反应。结果本组38例患者治疗期间流感样症状发生率最高,为68.4%,患者主要表现为发热、鼻塞、关节肌肉痛,其次脱发的发生率为47.4%。肝功能损害、骨髓抑制反应、神经系统症状、皮疹的发生率分别为39.5%、28.9%、15.8%、7.9%。结论聚乙二醇干扰素α-2a治疗慢性丙型肝炎的不良反应较多,应引起临床医师的足够重视,一旦发生不良反应应迅速给予有效的对症处理,保证用药安全。
Objective To observe the adverse reactions of pegylated interferon α-2a in the treatment of chronic hepatitis C and to explore the effective treatment measures. Methods The clinical data of 38 patients with chronic hepatitis C treated in our hospital from January 2011 to January 2012 were retrospectively analyzed. All patients were treated with peginterferon alfa-2a, and adverse reactions were observed during the treatment . Results The incidence of influenza-like symptoms was highest in 38 patients (68.4%) during the treatment period. The main symptoms were fever, nasal congestion and joint muscle pain. The incidence of hair loss was 47.4%. The incidence of liver dysfunction, myelosuppression, neurological symptoms and rash were 39.5%, 28.9%, 15.8% and 7.9% respectively. Conclusion Peginterferon alfa-2a treatment of chronic hepatitis C more adverse reactions, should attract enough attention of clinicians in the event of adverse reactions should be promptly given effective symptomatic treatment to ensure drug safety.