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目的:探讨化疗在中晚期非小细胞肺癌患者中对淋巴细胞亚群的影响。方法:随机抽取本院收治的60例中晚期非小细胞肺癌患者编为实验组进行化疗,另选取同期体检的50例健康志愿者作为对照组。随访12月-15月,采用流式细胞仪技术分别对两组外周血淋巴细胞亚群进行检测计数。结果:两组间相比,实验组患者的CD3+、CD4+、NK细胞的数量以及CD4+/CD8+比值均低于对照组(P<0.05),而CD8+细胞的比例却高于对照组。化疗后CD3+、CD4+、CD4+/CD8+、NK均较化疗前升高(P<0.05),但CD8+不变(P>0.05)。结论:应用化疗治疗中晚期非小细胞肺癌,可明显改善患者的免疫功能。
Objective: To investigate the effect of chemotherapy on lymphocyte subsets in patients with advanced non-small cell lung cancer. Methods: A total of 60 patients with advanced non-small cell lung cancer admitted to our hospital were randomly divided into experimental group and chemotherapy group. Fifty healthy volunteers of the same period were selected as control group. Follow-up December to 15 months, using flow cytometry were detected in two groups of peripheral blood lymphocyte subsets. Results: Compared with the control group, the number of CD3 +, CD4 +, NK cells and the ratio of CD4 + / CD8 + in the experimental group were significantly lower than those in the control group (P <0.05), while the proportion of CD8 + cells in the experimental group was higher than that in the control group. After chemotherapy, the levels of CD3 +, CD4 +, CD4 + / CD8 + and NK were higher than before chemotherapy (P <0.05), but CD8 + was unchanged (P> 0.05). Conclusion: The application of chemotherapy in the treatment of advanced non-small cell lung cancer can significantly improve the patient’s immune function.