1975年 Rheinwald 和 Green 首先报道了人角质细胞培养方法,在此基础上可实现在严重烧伤病人取一小块皮片,经培养增殖后移植回烧伤创面的新的治疗方法。1981年 O’Connor 和1984年 Callico首先成功地用这种自体角质细胞培养移植治疗深度烧伤。1987年我们也建立了角质细胞培养和移植的 1975 Rheinwald and Green first reported the human keratinocyte culture method, on the basis of which can be achieved in patients with severe burns to take a small piece of skin graft, after the proliferation of transplanted back to the wound treatment of new treatments. In 1981, O’Connor and Callico in 1984 first successfully used this autologous keratinocyte transplantation for deep burn injury. In 1987 we also established keratinocyte culture and transplantation