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洋红霉素(Carminomycim,Carubicin)是从洋红放线菌中分离得到的抗肿瘤抗生素,它对多种实验肿瘤有效,与其它蒽坏类似物同样有效情况下,无心脏毒性.与亚德里亚霉素的生物化学性质类似,但它口服与皮下注射能很好的吸收,其有效量比亚德里亚霉素低及最佳量是亚德里亚霉素的1/5至1/10.虽然它对白血病L1210和P388作用较差,但它对亚德里亚霉素无效的肿瘤有明显的疗效.鉴于苏联的深入研究及苏联和欧洲也进行了Ⅰ期临床研究,本文研究了洋红霉素对曾用过环磷酰胺,MTX,5-FU(CMF)或再联用长春新碱和强的松(CMFVP)患有转移性乳腺癌病人的实用价值,另外作为转移性疾病的辅助治疗或治疗.
Carminomycin (Carubomycin) is an antitumor antibiotic isolated from magenta actinomycetes, which is effective against a variety of experimental tumors and has no cardiotoxicity, as well as other anthracycline analogs, The biochemical properties of the hormone are similar, but it is well absorbed orally and subcutaneously, and its effective amount is lower and optimally 1/5 to 1/10 that of adriamycin, although it L1210 and P388 have a poor effect on leukemia, but it has obvious curative effect on Adriamycin-ineffective tumors.In view of the deep research in the Soviet Union and Phase I clinical studies in the Soviet Union and Europe, The utility of cyclophosphamide, MTX, 5-FU (CMF) or a combination of vincristine and prednisone (CMFVP) in patients with metastatic breast cancer, in addition to metastatic disease adjuvant therapy or treatment.