论文部分内容阅读
SMADs是新近发现的参与TGF β超家族的信号在细胞内传导的一族蛋白 ,包括 8个成员 ,分别称SMAD1～ 8。SMAD1、2、3、5和 8属于一类 ,它们被TGF β的受体或BMP的受体激活而磷酸化 ,称为受体调节SMAD ,传导TGF β或BMP的信号。SMAD6和 7属于另一类 ,它们抑制受体调节SMAD的信号传导。SMAD4是第三类 ,它是受体调节SMAD传导信号的伴侣。受体调节SMAD传导信号必须先与SMAD4结合形成异源复合物 ,才能进到核中 ,调节转录活动
SMADs are a newly discovered family of proteins that are involved in the signaling of the TGF β superfamily and are cell-mediated in nature and include 8 members, called SMADs 1 to 8, respectively. SMADs 1, 2, 3, 5, and 8 belong to a class that are phosphorylated by receptor activation of TGFβ or BMPs and are known as receptors that regulate SMADs and transmit TGFβ or BMP signaling. SMAD6 and 7 belong to another group, they inhibit the receptor modulate SMAD signaling. SMAD4 is the third group, which is the partner of the receptor to regulate SMAD-transduced signals. Receptor-regulated SMAD signaling must first combine with SMAD4 to form heterologous complexes to enter the nucleus and regulate transcriptional activity