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乳酸脱氢酶同功酶(LDH-C_4)存在于人的睾丸、精子和精液中。这种酶存在于初级精母细胞和生殖细胞系的较晚阶段,其在精液中的活性被认为是精子或其前体细胞漏出的表现。LDH-C_4约占精子中总LDH活性的80%,已知其与睾丸成熟有关,某些睾丸功能障碍则伴有这种酶的消失。生化分析精液中的器官特异性标记物可研究产生这些标记物的器官的分泌功能。已知前列腺的标记物有酸性磷酸酶、锌、镁离子、枸橼酸,精囊的标记物为果糖和前列腺素。由于LDH-C_4专门与生精上皮内的几种细胞有关,故其可成为这些细胞的标记物。精液LDH-C_4的半定量分析已用于鉴
Lactate dehydrogenase isoenzyme (LDH-C_4) exists in human testis, sperm and semen. This enzyme is present at the later stages of primary spermatocytes and germ cell lines and its activity in semen is considered as a manifestation of the leakage of sperm or its precursor cells. LDH-C_4 accounts for about 80% of the total LDH activity in sperm and is known to be associated with testicular maturation, with some of the testicular dysfunction associated with the loss of this enzyme. Biochemical analysis of organ-specific markers in semen allows the study of the secretory function of the organ in which these markers are produced. Known prostate markers acid phosphatase, zinc, magnesium, citric acid, seminal vesicle markers for fructose and prostaglandins. Since LDH-C_4 is specifically associated with several cells within the seminiferous epithelium, it can be a marker for these cells. Semi-quantitative analysis of semen LDH-C_4 has been used for reference