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目的观察扶正解毒祛瘀方药联合化疗治疗乳腺癌术后的临床疗效。方法将45例患者采用数字表法随机分为联合组(23例)与对照组(22例)。两组均采用CTF方案化疗,21天为1个周期,联合组同时加用扶正解毒祛瘀方药;2个化疗周期后,观察卡氏评分、体质量、免疫功能、肿瘤标志物及生存质量变化情况。结果联合组卡氏评分疗效、体质量疗效总有效率分别为87.0%和91.3%,对照组分别为27.3%和63.6%;组间卡氏评分疗效比较,差异有统计学意义(P<0.05)。治疗后联合组CD3、CD4/CD8、NK细胞水平明显升高(P<0.05,P<0.01),CD8细胞水平下降(P<0.01);对照组治疗后CD3、CD4、CD4/CD8、NK细胞水平下降(P<0.05,P<0.01),CD8水平升高(P<0.05);组间治疗后比较,各指标差异均有统计学意义(P<0.05,P<0.01)。联合组治疗后CEA和CA153较治疗前降低(P<0.05),对照组CEA较治疗前降低(P<0.05);组间治疗后比较,CEA、CA153差异均无统计学意义(P>0.05>)。两组生理状况、情感状况、功能状况、附加关注积分治疗前后组内比较,差异均有统计学意义(P<0.05,P<0.01);组间治疗后比较,生理状况、情感状况、功能状况和附加关注积分差异有统计学意义(P<0.01)。结论扶正解毒祛瘀方药联合化疗可明显提高乳腺癌术后患者的生活质量,改善免疫功能。
Objective To observe the clinical effect of Fuzheng Jiedu Quyu Recipe combined with chemotherapy on postoperative breast cancer. Methods 45 patients were randomly divided into the combined group (23 cases) and the control group (22 cases) by the digital meter method. Both groups were treated with CTF chemotherapy, 21 days for a cycle, combined with Fuzheng Jiedu Quyu prescription; 2 cycles of chemotherapy, the observed card’s score, body mass, immune function, tumor markers and quality of life changes Happening. Results The total effective rate of curative effect and body mass curative effect were 87.0% and 91.3% in the combined group and 27.3% and 63.6% in the control group respectively. There was significant difference in the curative effect between the two groups (P <0.05) . After treatment, the levels of CD3, CD4 / CD8, NK cells in the combined group were significantly increased (P <0.05, P <0.01) (P <0.05, P <0.01) and CD8 levels (P <0.05). There was significant difference between the two groups after treatment (P <0.05, P <0.01). CEA and CA153 in the combination group were significantly lower than those before treatment (P <0.05), and CEA in the control group were lower than those before treatment (P <0.05). There was no significant difference in CEA and CA153 between the two groups after treatment (P> 0.05) ). There were significant differences between the two groups in physiological status, emotional status, functional status and additional attention points before and after treatment (P <0.05, P <0.01). After treatment, the physiological status, emotional status, functional status And additional attention points difference was statistically significant (P <0.01). Conclusion Fuzheng Jiedu Quyu Recipe combined with chemotherapy can significantly improve the quality of life of postoperative patients with breast cancer and improve immune function.