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目的探究艾塞那肽对2型糖尿病的治疗效果。方法选取郴州市第一人民医院中心医院2012年11月至2013年11月由门诊收入我科治疗的2型糖尿病住院患者46例为研究对象,采用艾塞那肽治疗,对比分析治疗前后患者的空腹血糖值、糖化血红蛋白值、餐后2 h血糖值以及体质量等情况,并分析不良反应。结果治疗前患者低血糖发生率为32.61%,治疗后不良反应发生率为26.09%,低血糖的发生率为15.00%。治疗前后患者空腹血糖比较差异有统计学意义(t=3.9874,P=0.01),糖化血红蛋白值的比较差异有统计学意义(t=6.1469,P<0.01),餐后2 h血糖值比较差异有统计学意义(t=6.6954,P<0.01),体质量比较差异有统计学意义(t=2.1328,P=0.0359)。结论艾塞那肽治疗2型糖尿病取得了显著的临床效果,能有效控制血糖,改善胰岛B细胞功能,降低体质量,安全性高,具有高度的临床使用价值。
Objective To investigate the therapeutic effect of exenatide on type 2 diabetes mellitus. Methods Forty-six patients with type 2 diabetes mellitus treated in our department from November 2012 to November 2013 in Central Hospital of First People’s Hospital of Chenzhou City from November 2012 to November 2013 were selected as study objects. Exenatide treatment was used to compare the patients before and after treatment Fasting blood glucose, glycosylated hemoglobin, 2 h postprandial blood glucose and body weight, etc., and analysis of adverse reactions. Results Before treatment, the incidence of hypoglycemia was 32.61%. The incidence of adverse reactions was 26.09% and the incidence of hypoglycemia was 15.00% after treatment. The difference of fasting blood glucose before and after treatment was statistically significant (t = 3.9874, P = 0.01), and the difference of HbA1c was statistically significant (t = 6.1469, P <0.01) Statistical significance (t = 6.6954, P <0.01), body weight difference was statistically significant (t = 2.1328, P = 0.0359). Conclusion Exenatide treatment of type 2 diabetes has achieved remarkable clinical effects, which can effectively control blood sugar, improve the function of islet B cells, reduce body weight, high safety, and has a high clinical value.