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探讨IL-2/LAK细胞与放疗和/或化疗联合治疗晚期恶性肿瘤的价值。方法:本组共30例,其中单纯IL-2/LAK细胞治疗 5例(包括 2例TIL细胞胸腹腔灌注),IL-2/LAK细胞联合放疗18例(包括 1例动脉灌注),IL-2/LAK细胞联合化疗4例(包括1例动脉灌注),IL-2/LAK细胞联合放疗和化疗3例。结果:完全缓解率20.0%(6/30),总有效率 50.0%(15/30),其中单纯IL-2/LAK治疗有效率 20.0%(1/5),联合治疗有效率 56.0%(14/25)。2例 Kaposis’s肉瘤采用IL-2/LAK细胞联合放、化疗均达完全缓解,1例乳腺癌术后大量胸水用 TIL细胞+IL-2治疗达完全缓解。结论:IL-2/LAK细胞是有效的肿瘤过继性免疫疗法,和放、化疗联合应用可能有助于提高疗效。
To investigate the value of IL-2 / LAK cells combined with radiotherapy and / or chemotherapy in the treatment of advanced malignant tumors. Methods: A total of 30 cases were treated with IL-2 / LAK cells in 5 cases (including 2 cases of TIL cells by thoracic and abdominal cavity perfusion), IL-2 / LAK cells combined with radiotherapy in 18 cases (including 1 case of arterial perfusion) 2 / LAK cells combined chemotherapy in 4 cases (including 1 case of arterial perfusion), IL-2 / LAK cells combined with radiotherapy and chemotherapy in 3 cases. Results: The complete remission rate was 20.0% (6/30) and the total effective rate was 50.0% (15/30). The effective rate of simple IL-2 / LAK treatment was 20.0% (1/5) Efficiency 56.0% (14/25). 2 cases of Kaposis’s sarcoma with IL-2 / LAK cells combined radiotherapy and chemotherapy are up to complete remission, a large number of cases of breast cancer with TIL cells + IL-2 after treatment of complete remission. Conclusion: IL-2 / LAK cells are effective tumor adoptive immunotherapy, combined with radiotherapy and chemotherapy may help to improve the curative effect.