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目的比较埃索美拉唑针和奥美拉唑治疗十二指肠球部溃疡出血的疗效。方法 66例十二指肠球溃疡出血患者随机分为对照组和治疗组,对照组给予奥美拉唑治疗,治疗组给予埃索美拉唑治疗。结果对照组总有效率90.91%,治疗组总有效率96.97%。对照组头痛2例,腹胀、腹泻5例,皮疹1例,转氨酶轻度升高1例;治疗组头痛1例,腹胀、腹泻2例。两组患者用药前后血常规、尿常规、肾功能均无明显变化。结论埃索美拉唑治疗十二指肠球部溃疡出血疗效显著,不良反应少于奥美拉唑。
Objective To compare the efficacy of esomeprazole and omeprazole in the treatment of bleeding of duodenal ulcer. Methods 66 patients with duodenal ulcer hemorrhage were randomly divided into control group and treatment group. The control group was treated with omeprazole, and the treatment group was treated with esomeprazole. Results The total effective rate of the control group was 90.91%, the total effective rate of the treatment group was 96.97%. The control group had 2 cases of headache, abdominal distension, 5 cases of diarrhea, 1 case of rash and 1 case of mild aminotransferase. The treatment group had 1 case of headache, 2 cases of abdominal distension and diarrhea. Two groups of patients before and after treatment of blood, urine, kidney function were no significant changes. Conclusion Esomeprazole treatment of duodenal ulcer bleeding significant effect, adverse reactions less than omeprazole.